Nixa traces its origins back to the mid-1800s with the movement of farmers and traders into this fertile soil region of Southwest Missouri. The growing community quickly became known as a stopover or crossroads site, as the community was a half-day ride with a team. As with many other communities in Southwest Missouri, Nixa's early economy was based on agriculture and farming. Grain crops, dairy and beef cattle, and vegetables were the primary products of the area. Since most early residents of Nixa had little cash, "swapping of goods" was a common practice - - wood for flour, molasses for bran, and beef for horses from Springfield.
Throughout the last 150+years Nixa has become one of the fastest growing cities in the state of Missouri. The population has grown from 756 people in 1922 to 19,220 in 2012 according to The Nixa Chamber of Commerce, the rise in Nixa home sales and Nixa real estate development has tripled.
Rapid residential home growth has spurred new business development in Nixa. Several new retail, convenience and service-oriented businesses have located in the community since 1990 and expansion of existing industries is under way. Financial institutions like Liberty Bank, People’s Bank and Empire bank have constructed new offices and Springfield hospitals Mercy and Cox Health Center have opened satellite medical clinics to serve the growing Nixa population. Improved community facilities and services, such as the Nixa Community Center, police station and utility office, have been developed to serve the needs of the Nixa population into the 21st century.